I played a Maestro'D who became a Hocus. Her Hot and Weird were both at +3 by that point, so I imagined that for her, they were effectively the same thing, so all manipulation was the same thing, whether it was social, sexual or pychic. The Maelstrom was her establishment, here followers were her crew, she had become one with her fire. Then it all fell apart and she had to escape to safety. I loved that character.
I had an Angel who became a Hardholder, basically taking over after she had had enough. She was the third Hardholder of the game.
I've seen Hardholder to Battlebabe, which was the "fuck it already" arc others have mentioned. Battlebabe to Touchstone, when someone who tried desperately to remain detached decided to take on a cause. Skinner to Hardholder, when the puppetmaster decided to just be the master. Chopper to Battlebabe, when the leader of gang of children decided to grow up and become independent.