So, my local hobby shop runs an event once a year called
40 Hours of 40K, which is a 40-hour marathon of
Warhammer 40K themed events. They try to change it up so that it's not just miniatures wargaming - they have auctions, prize competitions, trivia, and a couple of RPG sessions.
I ran one of the latter last year, using FFG's Deathwatch game. The adventure was fine, but since I'm running an event halfway through a marathon, none of the players have the mental acuity necessary to play the complicated rules system; it's complex enough some people have trouble comprehending all the fiddly bits when wide awake.
So, I think The Regiment can be reskinned/hacked to do this quite well, and the system is simple enough that I think they players will be able to actually have fun.
Space Marines in the setting are genetically-modified supermen, religious zealots waging a war against the Enemies of Mankind. Each Chapter has it's own line of genetic material which it uses when a new Space Marine is chosen and the regimen begins. They receive implanted artificlal organs to give them superpowers and hypnotraining to develop abilities far beyond those of mortal men. Each chapter also has its own unique religious doctrine.
I'm thinking the chapters could each give the Marine one move, then they could select two moves from their playbook. I need to sit down with the rulebook and see what moves are appropriate for each type of Space Marine. "Grit" would be reskinned as "Faith." Smokes I'd get rid of entirely, since they're pretty monastic.
I haven't had a lot of time to play around with it yet, but I think it looks promising. Any thoughts?