It makes a big difference whether your entire game is happening inside the Hardhold in question, or whether it is only one of several centers of local power. My experience as both a player and MC is that the latter is preferable, when there is an actual Hardholder PC. Ideally you have some number of PCs who are internal to the Hardholder's place/power, and some number who exist on its periphery, or even have their own deals going on, or have some complicated relationship with the place.
My one real piece of meta-advice is to be careful about letting the social lines settle; by which I mean, always be ready to take the opportunity to redefine where the boundaries are, between people who are and are not loyal to the 'hold, to the Hardholder, to the other PCs, to the other NPCs, etc. These social circles and relationships are one of the things that you should look at through crosshairs, and if you play with your Agenda/Principles in mind you will inevitably end up with numerous, overlapping circles of loyalty and dependence. This is easiest to see/do when you have a Chopper or Hocus or Operator PC in addition to the Hardholder, and it is most at risk of not happening when none of those PCs are present. I like to think of it as the slightly-larger-scope version of making PC-NPC-PC triangles.
At the beginning, the easiest way to complicate these lines is to add new, as-yet-unnoticed circles or relationships -- the NPC leader of hardhold security turns out to also be part of an extended family, or one of the Operator's crew turns out to have history with the Hardholder (or even better, another PC who has aligned themselves firmly with the Hardholder.)
Then, once you have passed that initial stage, you can start complicating things by putting pressure on and crosshairs-ing it up with the existing circles, to see what happens.
Again, this is all happening according to Agenda/Principles, etc., but I do think it's something to look out for; it's not that every 'hold has to be some hotbed of intrigue and dissent, but if a status quo is starting to develop around the Hardholder's authority, such that they are calling all the shots and everyone else is just sort of following-through on their behalf, then you should make an effort to complicate the picture of the loyalties involved.