There's something really fascinating about the entire game's attitude to the line between friendship and manipulation, as evinced by the fact that the only way you can, mechanically, make an NPC start functioning like an actual friend and ally rather than a threat, is by hitting a 12+ advanced seduce or manipulate.
Contrast this with the Growing Up moves from Monsterhearts, where you start actually supporting your friends by figuring out how to do something *other* than manipulate them.
We're left with a choice between optimistic and pessimistic readings of the move (and by inference, of the Skinner's character, since the Skinner is archetypically central for seduce and manipulate -- the Skinner is to seduce what the Gunlugger is to seize by force, right?).
Optimistically, the move -- or at least its advanced version -- has to be read broadly, to include not just actual manipulation of people as tools, but every social dealing which alters your relationship with them. In this reading, the AW characters are already grown ups and have the equivalent of MH's grownup moves, so seduce/manip can mean calling people on their shit, making them feel beautiful, standing up to them, telling them the truth about themselves, inspiring them, showing them true beauty that lifts them out of their selfish defensive isolation, authentically revealing our own vulnerability and sharing our own pain and our compassion for theirs, etc. All the things you would actually do to turn someone from a potential threat to a true confidante/ally/etc.
The pessimistic reading is that seduce/manipulate means what it says on the jar, that manipulate means treating people as tools and seduce is specifically not sex for its own sake but sex in order to get something, and that therefore the 12+ option simply underlines the dark truth of AW's social relations -- everyone is a threat, and the only people (or at least the only NPCs, but let's not kid ourselves, the other PCs are always a threat too in this game) who aren't a threat are the poor fools you've super-seduced into permanently putting your interests before their own -- and however much affection you might have for them in return, it should never be forgotten that the relationship is based on an instance of manipulation, that they are necessarily suckers, your tools first and your friends second.
I'm not sure which reading I favor; maybe what's most intended is the tension between them, and being the Skinner means never being entirely easy in those relationships, even the ones you really hope are really friendships, because their core lies uncomfortably close to your powers of manipulation...
And all this stuff is if anything even more interesting with the Yo-Yo-Ma skinner who seduces by creating beautiful art and not by showing some leg.