I don't know if you guys are talking from the same point of view, here. Mean Liar seems to be saying that the NPCs aren't real people. Well... obviously. I'm not sure that's an issue with the system in Apocalypse World. NPCs aren't real people and there's no real consequence for not treating them as real people except that your game might kind of suck. It's as true in D&D or Shadowrun or Burning Wheel or Star Wars or whatever as it is in Apocalypse World.
I think certain players approach the game as a problem to decomplexify. In their point of view, the end goal is to have a system you can control. Be the king and have only loyal subjects and plenty of resources for that number of people. See, that's a simple system. Because there are only loyal subjects, there will be no attempts to subvert your rule or muck up your resource situation. How do you get there from a complex field with multiple powers in play and limited resources? The easiest way is to kill everybody who's not a loyal subject (and take their resources). It's not really roleplaying unless you're playing high-functioning sociopaths, but it is a game.
It's not a game that AW plays well, I suspect. To have a satisfying game of "kill all the opposition" you probably want stats for them so that so-and-so can be too powerful to kill by just ringing his doorbell and blowing him all to hell. AW doesn't do that naturally. You could give him a large 4 harm gang with 2 armor and bunkers and have him hide there like a bitch, but what's the point? Even then, the PCs can probably sneak in or subvert his gangers or whatever. You could make a custom move like this:
When you fight Mary Sue, roll +Hard. On 10+, choose 1. On 7-9, choose 2. On a miss, the MC will kill you in a spectacular fashion.
- You lose a limb or your genitals.
- You cry like a little baby.
- You are horribly scarred and no one will love you again.
- You can breathe okay as long as the machines stay on.
But, you know, your players might whine.
AW isn't made to describe the high-functioning sociopath game. The players, like the MC, have to make Apocalypse World seem real. Real people don't execute everyone around them to simplify their lives. Real people get involved in relationships and try to make other people happy, often at expense of their own wishes, and stuff like that. If you buy in, you get a fun game. If not, that's okay, just find something more "gamist" and less "color-first" or whatever that phrase Vincent uses is.