Well this is very situational, and I struggle with it too. Unfortunately you just have to be creative in the moment, here are some general ideas I use though:
You're running along the rooftops away from the crazy dude with the pickaxe. You're about to get away clean when you see little Twice is curled up napping in a nook of the last rooftop. You're out of here, but that will leave him alone right in the path of the crazy guy.
You're running along the rooftops, but the going is super tough. You slipped a couple times, and the crazy guy is practically on top of you. Up ahead though is a gas tanker parked between buildings. It's all old and beat up; you can smell the leaking gas from here. If you lit that thing on fire as you passed, it would block the path behind you. It would set the damn town on fire though.
(In a different town you could have a levee with a release, or a bridge to collapse, etc.)
You're running along the rooftops, but so is your assailant. You don't know how, but he's gaining on you. Looking at the roofs ahead, you don't think you can outrun him to [the place you're running], but you could probably make a break for [that dangerous place you'd rather avoid] and lose him there.
(Dangerous place can also be dangerous people. Out of one frying pan and into another. Generally thats the sort of thing I do. If you miss the roll you escape from one danger, but arrive at another.)
You're running along the roofs and pulling away from your attacker. You catch a glimpse of something through a hole in a roof though. You aren't sure what it was, but you think there's treasure to be had. No way you'll be able to find your way back here later, do you want to try for it or leave it be?
(The treasure can be explicitly described or not. Perhaps it's some rivals's horde, or an untouched stash of stuff from the golden age, or perhaps it's a beautiful man/woman, or music faintly heart, or a scent of perfume, or a vibration in the maelstrom. Whatever would tempt this particular character. The "try for it" could be a lot of things too.)
Those are some of the things I do in that situation. Basically though, just look at the list of MC Moves, all of them work for this. Put them in a spot. Separate them. Capture them. Tell them consequences and ask. Etc. The only trick is that you can't make these moves as hard or direct as you might otherwise. "Capture them" can be having them rescued by someone who they'll owe for the help. Make sense?