Thanks, Vincent!
It was my experience that it worked pretty well. But it was very easy for a) the various characters to feel like they were playing totally different games (the Brainer is dealing with the mudfish plague while the Chopper is off attacking Ambergrease, for example), and b) end in a giant and kind of messy battle over the hardhold (which similarly leaves non-combat characters with little to do).
We had trouble with the incredible number of NPCs and possible directions for play, as well.
I don't know how universal my experience is.